No. Our patients do not and have not experienced delayed reactions. Our precise dose calculations are based on date. All challenges are performed in a fully-monitored format over a 10 to 15 minute period of time. After digestion, our patients are stressed with rigorous exercise in order for them to achieve a high heart rate while under our observation. This approach reduces the risk of a delayed reaction. In over 50,000 in-house challenge, we have had no incident of delayed reaction.