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Expand Your Toolkit

Add the Tolerance Induction Program™ (TIP) to your toolkit to improve your patients' quality of life and change food allergies as a disease state.

For some food allergy patients, avoidance or desensitization through Oral Immunotherapy (OIT) may be an effective method of food allergy management. However, for those seeking a safe, non-avoidance solution to eat freely without restriction, there is the Tolerance Induction Program. TIP is also ideal for patients with severe or complex cases that may not qualify for traditional treatment methods. 

Through TIP, patients go beyond desensitization and can achieve remission—seven days of sustained immune unresponsiveness with weekly protein exposure.

Biosimilar Immunotherapy: A Non-Avoidance  Approach

Biosimilar Proteins-02-2

We study and leverage taxonomic relationships to identify and predict biosimilar proteins to treat a wide variety of food allergies. Biosimilar proteins are safe, non-allergenic proteins that have evolutionarily conserved structural components with an allergic protein but do not elicit a reaction. 

The Tolerance Induction Program™ (TIP) reconditions the immune system to tolerate allergic proteins by introducing biosimilar foods, leading to a decrease in allergen-specific IgE, an increase in allergen-specific IgG4, and immune modulation (B cells and T cells) that, in many cases, eliminates food anaphylaxis.

Once a patient’s IgE levels have been decreased through biosimilar conditioning, patients will be introduced to increasing amounts of their allergen until true tolerance and remission are achieved. This safe and gradual approach significantly reduces the risk inherent to direct exposure. See our public reaction rates. 

Patient Profiles May Include:
  • Patients with diagnosed food allergies, anaphylaxis, or who carry an Epinephrine auto-injector (EAI)
  • Patients with multiple IgE-mediated reactions but no anaphylaxis ( they may be carrying an EAI)
  • Patients with level 1 or higher on RAST Panel to food
  • Patients who need to be tested for food allergies
Pantaleon: A Food Allergy EMR Driven By Machine Learning

Pantaleon’s proprietary machine-learning systems leverage patient diagnostic data and medical history to predict and generate an accurate, detailed allergen “Snapshot” and the optimal treatment plan—down to the milligram of food dosed—to achieve food allergy remission. The Snapshot visually represents the foods and proteins a child is allergic to and the severity of their allergy.

Watch the video below to learn more about Pantaleon.

Clinical Differentiation Between TIP and OIT

TIP offers a safer, more advanced, and personalized path to food freedom compared to OIT’s desensitization-based approach.

  • Safety
      TIP is designed to be safer, minimizing reaction risk through biosimilar protein conditioning and a data-driven, personalized approach. In contrast, OIT,—including Palforzia—carries a higher risk of reactions and gastrointestinal (GI) issues due to direct allergen exposure.2,3,4,5
  • Treatment Goal 
      TIP aims for true remission, allowing patients to eat freely without ongoing maintenance, whereas OIT focuses on desensitization, requiring lifelong daily dosing to maintain tolerance.1
  • Personalization 
      TIP uses AI-driven immune profiling to customize treatment for each patient based on biomarkers, whereas OIT follows a standardized protocol for individual allergens.1
  • Multi-Allergen Treatment 
      TIP treats multiple food allergies simultaneously, while OIT typically targets one allergen at a time.1
  • Diagnostic Testing & Monitoring 
      TIP relies on advanced diagnostics—such as IgE, IgG4, skin prick, and basophil activation tests—to track immune shifts, while OIT has limited ongoing immune monitoring.6,7
  • Dosing & Lifestyle Impact 
      TIP eliminates lifelong dosing and rest periods, allowing a more flexible lifestyle, whereas OIT requires strict daily dosing and activity restrictions.1
Key Statistics
91 %
of TIP patients have multiple food allergies
76 %
of TIP patients have underlying health conditions
56288
Foods have been Introduced and Challenged
< 1 %
Reaction rate
View Our Data Dashboard
Peanut Remission Journey
Rectangle 43

Sophia

Verified Patient of TIP Focus: Peanut Years in Program: 3 Years

Sophia has been cleared for cross-contact for Peanut. It has opened up so many new foods to try, made daily life and travel a million times easier. Dining out and social events finally feel FUN.

IgE Levels
  • IgE Before TIP
    |0 |50 |100
  • IgE After 2 Years of TIP
    |0 |50 |100
  • IgE in Remission
    |0 |50 |100

* This journey is provided for illustrative purposes only

Immune System Mapping and Testing

All TIP patients undergo a skin prick test, basophil activation tests, and in-depth blood testing to capture a complete and accurate image of the immune system. Multiple testing methods help mitigate false positives. 

While a food challenge is the standard practice, TIP patients typically only challenge a food once their biomarkers indicate it is safe to do so.
Blood Testing

Food Allergy Institute operates its own diagnostic laboratory to ensure the highest level of accuracy and consistency in testing, which is essential for developing and maintaining highly individualized treatment plans in the Tolerance Induction Program.

  • Advanced, Customized Testing Protocols
      We conduct advanced component testing to identify specific proteins that trigger reactions, surpassing standard IgE blood tests. Customized for each patient, our precise methods detect subtle immune responses often missed by standard labs, reducing false results and unnecessary food restrictions. Additionally, all testing is overseen by immunology and allergy specialists, ensuring superior accuracy
  • AI-Driven and Data-Backed Analysis
      We use proprietary AI-driven models to analyze immune system patterns and predict potential reactions. Our data analysis goes beyond test results—it informs treatment and allows for real-time adjustments as patients progress through treatment.
  • Faster, More Precise Results
      Unlike general labs, that process thousands of unrelated tests, our lab is dedicated exclusively to food allergy diagnostics. This specialization enables us to deliver faster, more precise results that seamlessly integrate directly into treatment planning.
  • A Fully Integrated Treatment Mode
      By conducting our own testing, we can track immune system changes over time and adapt treatment accordingly. Our in-house biobank stores and analyzes patient data, enabling comparisons against thousands of cases for more personalized recommendations. Furthermore, patient data allows us to study the biological mechanisms that drive remission, deepening our understanding of the disease state.
Safe, Precision Dosing

Over 90% of TIP treatment is completed at home in 8-12 week treatment cycles, during which patients will gradually up-dose foods and condition their immune system with biosimilar proteins in preparation for in-office food challenges. To ensure the highest level of dosing safety and accuracy,  Food Allergy Institute’s in-house Food Laboratory manufactures, packs, and delivers 28 different allergen gummies to support TIP treatment.

  • Allergen Gummies
      Our allergen gummies contain precise milligram amounts of 28 different plant proteins including peanuts, all tree nuts, and various seeds. The gummies eliminate the guesswork in micro-dosing and ensure safe, accurate, and convenient dosing every time. Each allergen gummy comes in a unique kid-friendly flavor. See our gummy key. 
  • Continuous Innovation
      Our in-house Food Lab continually researches and develops new products to enhance dosing safety and efficiency, including shelf-stable allergen tablets and maintenance bars, making remission maintenance more convenient.

Our Team

Rectangle 32
Dr. Randhawa Board-certified Allergist, Food Allergy Institute Founder & CEO

Dr. Inderpal Randhawa is a leading clinical academic scientist with five board certifications in allergy, transplant immunology, pulmonology, pediatrics, and internal medicine. 

Distressed watching parents suffer the loss of a child to fatal allergic reactions, he proposed to find groundbreaking solutions and change the status quo of food allergy treatment. His early experience in lung transplant immunology, coupled with his collaboration with national allergy and immunology specialists, led him to develop the safe, targeted solutions now offered through the Food Allergy Institute (FAI).

Herman (1)
Herman Sandhu Senior Manager of Software Development

Herman Sandhu is a founding member of the Food Allergy Institute and a key architect behind Pantaleon, the groundbreaking machine-learning software that powers the Tolerance Induction Program™ (TIP). Alongside his team of data scientists, Herman plays a crucial role in processing patient data and developing personalized treatment plans for all TIP patients.

Marsteller
Dr. Nathan Marsteller Director of Research

Dr. Marsteller oversees one of the largest collections of food allergy bio-specimens at  Food Allergy Institute's parent company, TPIRC. His research serves as the foundation of the Tolerance Induction Program™ (TIP). Through his work, Dr. Marsteller and his team have made significant strides in advancing treatment for food anaphylaxis and other rare diseases.

Clark
Dr. Tracy Clark Vice President of Clinical Services

Dr. Tracy Clark oversees all clinical operations and staff at Food Allergy Institute's two Southern California locations. Since 2018, Dr. Clark has dedicated her career to helping food-allergic children at the Food Allergy Institute. She plays a pivotal role in maintaining our exemplary quality of care and enhancing the in-clinic patient experience. 

Shin
Shin Nagane Senior Food Scientist

Shin Nagane is the Senior Food Scientist at Food Allergy Institute’s in-house Food Lab. Shin is responsible for the continuous improvement of Food Lab products and the development of innovative dosing methods. Currently, Nagane is researching and developing allergen dosing tablets (TIP Tarts) and a maintenance bar to support patients in maintaining remission.

Ahn
Anh Duong Research Laboratory Manager

Anh Duong manages and maintains the research lab at Food Allergy Institute’s parent company, TPIRC. With over 25 years of experience in biological research, Duong conducts tests that contribute to Food Allergy Institute patient profiles. In addition to running experiments and analyzing data, he trains scientists, fellows, volunteers, technicians, and others interested in the lab’s work.

Peter
Peter Ngo Diagnostic Laboratory Manager

Peter Ngo oversees Food Allergy Institute’s in-house diagnostic testing facility, enforcing strict operating procedures to ensure data accuracy, quality, and reproducibility. Maintaining high-quality data is essential to ensuring the accuracy of the machine-learning software that generates TIP treatment plans.  All TIP patients undergo in-depth blood testing through our in-house diagnostic facility. 

Partner with Food Allergy Institute View Our Publications

 

Sources:


1. American Academy of Allergy, Asthma & Immunology. (n.d.). The current state of oral immunotherapy. AAAAI. Retrieved February 19, 2025, from https://www.aaaai.org/tools-for-the-public/conditions-library/allergies/the-current-state-of-oral-immunotherapy


2. Grzeskowiak, L.E., Tao, B., Knight, E. et al. Adverse events associated with peanut oral immunotherapy in children – a systematic review and meta-analysis. Sci Rep 10, 659 (2020). https://doi.org/10.1038/s41598-019-56961-3


3. Leeds, S., Kuster, J. K., & Wang, J. (2022). A review of the safety of oral immunotherapy in clinical trial and real-world studies. Journal of food allergy, 4(2), 34–39. https://doi.org/10.2500/jfa.2022.4.220009

4. Chu, D. K., Wood, R. A., French, S., Fiocchi, A., Jordana, M., Waserman, S., Brożek, J. L., & Schünemann, H. J. (2019). Oral immunotherapy for peanut allergy (PACE): a systematic review and meta-analysis of efficacy and safety. Lancet (London, England), 393(10187), 2222–2232. https://doi.org/10.1016/S0140-6736(19)30420-9

5. Chaplin, S. (2021). Palforzia for desensitisation of peanut allergy in children. Prescriber, 32(6), 33-34. https://doi.org/10.1002/psb.1928


6. Ponce, M., & Berin, M. C. (2016). Markers of tolerance development to food allergens. Allergy, 71(11), 1393–1404. https://doi.org/10.1111/all.12953


7. Burks, A. W., Jones, S. M., Chung, Y., Sicherer, S., Wood, R. A., Henning, A. K., Lindblad, R., Stablein, D., & Sampson, H. A. (2018). Immune mechanisms of oral immunotherapy. Journal of Allergy and Clinical Immunology, 141(2), 491–498. https://doi.org/10.1016/j.jaci.2017.12.981